Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate

Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate - Names and Identifiers

Name	1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
Synonyms	ethyl 3H-imidazo[4,5-b]pyridine-6-carboxylate Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate 3H-Imidazo[4,5-b]pyridine-6-carboxylic acid, methyl ester 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester
CAS	77862-95-4

Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate - Physico-chemical Properties

Molecular Formula	C8H7N3O2
Molar Mass	177.16
Storage Condition	2-8°C

Methyl 1H-iMidazo[4,5-b]pyridine-6-carboxylate - Introduction

1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester (1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester) is an organic compound with the formula C10H9N3O2.

Nature:
-Appearance: Colorless to light yellow crystal powder;
-Solubility: Soluble in organic solvents such as dimethyl sulfoxide, dimethylformamide and ethanol, insoluble in water;
-Melting point: about 115-118°C.

Use:
- 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester is commonly used as a drug intermediate;
-It can be used to synthesize biologically active substances, such as anti-cancer drugs, anti-inflammatory drugs, etc.

Preparation Method:
The synthesis of 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester is generally carried out through the following steps:
1. firstly, 3-amino -5-pyridine carbonyl chloride is reacted with propionyl formaldehyde to generate 3-amino -5-pyridine methanol;
2. Then, 3-amino -5-pyridine methanol is reacted with methyl aminopropionate to generate 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester.

Safety Information:
- 1H-IMidazo[4,5-b]pyridine-6-carboxylic acid, Methyl ester is relatively stable under general operating conditions, but it still needs to be handled carefully to avoid inhalation of dust and skin contact;
-in the use of the process, should wear appropriate protective equipment, such as chemical protective gloves, protective glasses and protective masks;
-Store it in a sealed manner, away from fire and oxidant, and avoid prolonged contact with air.

Last Update：2024-04-09 21:01:54